New York City

New York City is where Amy and Nick are living when they meet. They also live there for a few years after they marry. They leave New York City to move to Nick's hometown when his mother falls ill with cancer.

Carthage, Missouri

Carthage, Missouri is Nick's hometown. It is where Nick and Amy move to help Nick's mother when she's sick. Go is also living in Carthage at the time. Nick and Go open a bar together in Carthage. Amy goes missing from Carthage, Missouri, as well.

Hannibal

Hannibal is a town close to Carthage. Hannibal is the hometown of Mark Twain, so there are numerous tourist attractions honoring Mark Twain and his character Huck Finn. Hannibal is where Nick had a summer job growing up. Hannibal is one of the places Amy hides a clue in the treasure hunt for their fifth wedding...