Ondaatje's novel Anil's Ghost was adapted as an unabridged audiocassette and audio CD in 2000, both available from Bantam Books and both with Alan Cumming as reader.

Ondaatje's novel The English Patient was adapted as a feature film in 1996 by Miramax Films. Written and directed by Anthony Minghella, the film starred Ralph Fiennes, Juliette Binoche, Willem Dafoe, Kristin Scott Thomas, and Colin Firth. It is available on both DVD and VHS from Miramax Home Entertainment.

The English Patient was also adapted as an abridged audiocassette in 1993 by Random House. This audiobook is read by Michael York.