Directed by William Robert Daly, the 1914 silent film version of Uncle Tom's Cabin starred Mary Eline, Irving Cummings, and Sam Lucas. Lucas was one of the first African-American actors to appear in a leading movie role.

Another film version of Uncle Tom's Cabin (Onkel Tom's Hutte) was made in Yugoslavia in 1969 by Hungarian director Geza von Radvanyi and stars John Kitzmiller, O.W. Fischer, Herbert Lom, and Gertraud Mittermayr.

A made-for-television version of Stowe's novel, directed by Stan Lathan, appeared in 1987. This version stars Avery Brooks, Kate Burton, Bruce Dern, Paula Kelly, Phylicia Rashad, Kathryn Walker, Edward Woodward, Frank Converse, George Coe, and Albert Hall.