Keller's life is the basis of William Gibson's play The Miracle Worker, which includes many of the events of Keller's life as portrayed in The Story of My Life. The play was successful on the stage and was adapted to film in 1962, produced by Playfilm Productions and starring Anne Bancroft as Sullivan and Patty Duke as Keller. For their performances in the 1962 film version, Bancroft and Duke won Academy Awards for Best Actress and Best Supporting Actress, respectively. In 1970, a film called Helen Keller and Her Teacher was produced by Jerome Kurtz and Jesse Sandler.

The Miracle Worker has also been filmed for television. In 1979, the film was made starring Patty Duke as Sullivan and Melissa Gilbert as Keller. A newer version was broadcast in 2001, starring Hallie Kate Eisenberg as Keller and Alison Elliott as Sullivan.

A documentary featuring Keller herself was produced by Nancy Hamilton Presentation...