Come Back, Little Sheba was adapted as a film in 1952 it was produced by Hal B. Wallace for Paramount Pictures and stars Shirley Booth as Lola, Burt Lancaster as Doc, Terry Moore as Marie, and Richard Jaeckel as Turk. Booth won an Academy A ward for her performance.

A made-for-television version was presented on NBC in 1977. The cast includes Lawrence Olivier, Joanne Woodward, Carne Fisher, and Nicholas Campbell. It was produced by Granada Television.

A musical adaptation titled Sheba opened III 1974 III Chicago. It starred Kay Ballard, George Wallace, Kimberly Farr, and Gary Sand.