A number of Marquand's novels have become films and plays. George S. Kaufman and Marquand worked together to adapt The Late George Apley for Broadway production in 1947. The play ran for a year as did Point of No Return, dramatized in 1951 by Paul Osborn. Leland Hayward directed, and Henry Fonda starred as Charles Grey.

Films of Marquand's novels include H. M. Pulham, Esquire in 1941, B. E's Daughter in 1948, and Melville Goodwin, USA in 1956 under the title Top Secret Affair. The Late George Apley was filmed in 1947, and the Mr. Moto series over the twenty-year period between 1937 and 1957. In addition, Sincerely, Willis Wayde was a Playhouse 90 TV production in 1956.