would therefore vse inwardly by smells, or ontwardly by application, things of hot and drie qualitie, all the gaine that he could make thereof would onely be to put himselfe in a great forwardnesse for running mad, by ouer-watching himselfe, the coldnesse and moistnesse of our braine beeing the onely ordinarie meanes that procure our sleepe and rest.  Indeed I do not denie, but when it falls out that any of these, or any part of our bodie growes to be distempered, and to tend to an extremetie, beyond the compasse of Natures temperate mixture, that in that case cures of contrary qualities, to the intemperate inclination of that part, being wisely prepared and discreetely ministered, may be both necessarie and helpefull for strengthning and assisting Nature in the expulsion of her enemies:  for this is the true definition of all profitable Physicke.

But first these Cures ought not to bee vsed, but where there is neede of them, the contrarie where of, is daily practised in this generall vse of Tobacco by all sorts and complexions of people.

And next, I deny the minor of this argument, as I haue already said, in regard that this Tobacco, is not simply of a hot and dry qualitie; but rather hath a certaine venemous facultie ioyned with the heate thereof, which makes it haue an Antipathie against nature, as by the hatefull smell thereof doeth well appeare.  For the nose being the proper Organ and convoy of the sense of smelling to the braines, which are the onely fountaine of that sense, doeth euer serue vs for an infallible witnesse, whether that Odour which we smell, be healthfull or hurtfull to the braine (except when it fals out that the sense it selfe is corrupted and abused through some infirmitie, and distemper in the braine.) And that the suffumigation thereof cannot haue a drying qualitie, it needes no further probation, then that it is a smoake, all smoake and vapour, being of it selfe humide, as drawing neere to the nature of the ayre, and easie to be resolued againe into water, whereof there needes no other proofe but the meteors, which being bred of nothing else but of the vapours and exhalations sucked vp by the Sunne out of the earth, the Sea, and waters, yet are the same smoakie vapours turned, and transformed into Raynes, Snowes, Dewes, hoare Frostes, and such like waterie Meteors, as by the contrarie the raynie cloudes are often transformed and euaporated in blustering winds.

The second Argument grounded on a show of reason is, That this filthie smoake, as well through the heat and strength thereof, as by a naturall force and qualitie, is able and fit to purge both the head and stomacke of Rhewmes and distillations, as experience teacheth, by the spitting and auoyding fleame, immeadiately after the taking of it.  But the fallacie of this Argument may easily appeare, by my late preceding description of the Meteors.  For euen as the smoakie vapours sucked vp by the Sunne, and staied in the