When the spirit of animation is thus exhausted by useless exertions, the organ becomes torpid or unexcitable into action, and a second fit of quiescence succeeds that of abundant activity.  During this second fit of quiescence the sensorial power becomes again accumulated, and another fit of exertion follows in train.  These vicissitudes of exertion and inertion of the arterial system constitute the paroxysms of remittent fevers; or intermittent ones, when there is an interval of the natural action of the arteries between the exacerbations.

In these paroxysms of fevers, which consist of the libration of the arterial system between the extremes of exertion and quiescence, either the fits become less and less violent from the contractile fibres becoming coming less excitable to the stimulus by habit, that is, by becoming accustomed to it, as explained below XII. 3. 1. or the whole sensorial power becomes exhausted, and the arteries cease to beat, and the patient dies in the cold part of the paroxysm.  Or secondly, so much pain is introduced into the system by the violent contractions of the fibres, that inflammation arises, which prevents future cold fits by expending a part of the sensorial power in the extension of old vessels or the production of new ones; and thus preventing the too great accumulation or exertion of it in other parts of the system; or which by the great increase of stimulus excites into great action the whole glandular system as well as the arterial, and thence a greater quantity of sensorial power is produced in the brain, and thus its exhaustion in any peculiar part of the system ceases to be affected.

4.  Or thirdly, in consequence of the painful or pleasurable sensation above mentioned, desire and aversion are introduced, and inordinate volition succeeds; which by its own exertions expends so much of the spirit of animation, that the two other sensorial faculties, or irritation and sensation, act so much more feebly; that the paroxysms of fever, or that libration between the extremes of exertion and inactivity of the arterial system, gradually subsides.  On this account a temporary insanity is a favourable sign in fevers, as I have had some opportunities of observing.

III. Of repeated Stimulus.

1.  When a stimulus is repeated more frequently than the expenditure of sensorial power can be renewed in the acting organ, the effect of the stimulus becomes gradually diminished.  Thus if two grains of opium be swallowed by a person unused to so strong a stimulus, all the vascular systems in the body act with greater energy, all the secretions and the absorption from those secreted fluids are increased in quantity; and pleasure or pain are introduced into the system, which adds an additional stimulus to that already too great.  After some hours the sensorial power becomes diminished in quantity, expended by the great activity of the system; and thence, when the stimulus of the opium is withdrawn, the fibres will not obey their usual degree of natural stimulus, and a consequent torpor or quiescence succeeds, as is experienced by drunkards, who on the day after a great excess of spirituous potation feel indigestion, head-ach, and general debility.