But in those muscular fibres, which are subject to constant stimulus, as the arteries, glands, and capillary vessels, another phenomenon occurs, if their accustomed stimulus be withdrawn; which is, that the sensorial power becomes accumulated in the contractile fibres, owing to the want of its being perpetually expended, or carried away, by their usual unremitted contractions.  And on this account those muscular fibres become afterwards excitable into their natural actions by a much weaker stimulus; or into unnatural violence of action by their accustomed stimulus, as is seen in the hot fits of intermittent fevers, which are in consequence of the previous cold ones.  Thus the minute vessels of the skin are constantly stimulated by the fluid matter of heat; if the quantity of this stimulus of heat be a while diminished, as in covering the hands with snow, the vessels cease to act, as appears from the paleness of the skin; if this cold application of snow be continued but a short time, the sensorial power, which had habitually been supplied to the fibres, becomes now accumulated in them, owing to the want of its being expended by their accustomed contractions.  And thence a less stimulus of heat will now excite them into violent contractions.

If the quiescence of fibres, which had previously been subject to perpetual stimulus, continues a longer time; or their accustomed stimulus be more completely withdrawn; the accumulation of sensorial power becomes still greater, as in those exposed to cold and hunger; pain is produced, and the organ gradually dies from the chemical changes, which take place in it; or it is at a great distance of time restored to action by stimulus applied with great caution in small quantity, as happens to some larger animals and to many insects, which during the winter months lie benumbed with cold, and are said to sleep, and to persons apparently drowned, or apparently frozen to death.  Snails have been said to revive by throwing them into water after having been many years shut up in the cabinets of the curious; and eggs and seeds in general are restored to life after many months of torpor by the stimulus of warmth and moisture.

The inflammation of schirrous tumours, which have long existed in a state of inaction, is a process of this kind; as well as the sensibility acquired by inflamed tendons and bones, which had at their formation a similar sensibility, which had so long lain dormant in their uninflamed state.

3.  If after long quiescence from defect of stimulus the fibres, which had previously been habituated to perpetual stimulus, are again exposed to but their usual quantity of it; as in those who have suffered the extremes of cold or hunger; a violent exertion of the affected organ commences, owing, as above explained, to the great accumulation of sensorial power.  This violent exertion not only diminishes the accumulated spirit of animation, but at the same time induces pleasure or pain into the system, which, whether it be succeeded by inflammation or not, becomes an additional stimulus, and acting along with the former one, produces still greater exertions; and thus reduces the sensorial power in the contracting fibres beneath its natural quantity.