“The above experiments were made with blood taken from a small vein in the hand or foot of three or four different patients, whom I had at that time under inoculation.  They were selected from 160, as having the greatest number of pustules.  The part was washed with warm water before the blood was taken, to prevent the possibility of any matter being mixed with it from the surface.”

Shall we conclude from hence, that the variolous matter never enters the blood-vessels? but that the morbid motions of the vessels of the skin around the insertion of it continue to increase in a larger and larger circle for six or seven days; that then their quantity of morbid action becomes great enough to produce a fever-fit, and to affect the stomach by association of motions? and finally, that a second association of motions is produced between the stomach and the other parts of the skin, inducing them into morbid actions similar to those of the circle round the insertion of the variolous matter?  Many more experiments and observations are required before this important question can be satisfactorily answered.

It may be adduced, that as the matter inserted into the skin of the arm frequently swells the lymphatic in the axilla, that in that circumstance it seems to be there arrested in its progress, and cannot be imagined to enter the blood by that lymphatic gland till the swelling of it subsides.  Some other phaenomena of the disease are more easily reconcileable to this theory of sympathetic motions than to that of absorption; as the time taken up between the insertion of the matter, and the operation of it on the system, as mentioned above.  For the circle around the insertion is seen to increase, and to inflame; and I believe, undergoes a kind of diurnal paroxysm of torpor and paleness with a succeeding increase of action and colour, like a topical fever-fit.  Whereas if the matter is conceived to circulate for six or seven days with the blood, without producing disorder, it ought to be rendered milder, or the blood-vessels more familiarized to its acrimony.

It is much easier to conceive from this doctrine of associated or sympathetic motions of distant parts of the system, how it happens, that the variolous infection can be received but once, as before explained; than by supposing, that a change is effected in the mass of blood by any kind of fermentative process.

The curious circumstance of the two contagions of small-pox and measles not acting at the same time, but one of them resting or suspending its action till that of the other ceases, may be much easier explained from sympathetic or associated actions of the infected part with other parts of the system, than it can from supposing the two contagions to enter the circulation.