“19th.  The punctured parts of the right arm were surrounded with some degree of subcuticular inflammation. 20th.  The inflammation more considerable, with a slight degree of itching, but no pain upon pressure. 21st.  Upon examining the arm this day with a lens I found the inflammation less extensive, and the redness changing to a deep yellow or orange-colour, 22d.  Inflammation nearly gone. 23d.  Nothing remained, except a slight discoloration and a little scurfy appearance on the punctures.  At the same time the inflammation of the arm inoculated with variolous matter was increasing fast, and he had the disease mildly at the usual time.

“Experiment 2d.  I inoculated another child at the same time and in the same manner, with blood taken on the first day of the eruption; but as the appearance and effects were similar to those in the preceding experiment, I shall not relate them minutely.

“Experiment 3d.  October 20th.  Blood was taken from a person who had the small-pox, on the third day of the eruption, and on the sixth from the commencement of the eruptive fever.  I introduced some of it in its fluid state into both arms of a boy seven years old.

21st.  There appeared to be some inflammation under the cuticle, where the punctures were made. 22d.  Inflammation more considerable. 23d.  On this day the inflammation was somewhat greater, and the cuticle rather elevated.

“24th.  Inflammation much less, and only a brown or orange-colour remained. 25th.  Scarcely any discoloration left.  On this day he was inoculated with variolous matter, the progress of the infection went on in the usual way, and he had the small-pox very favourably.

“At this time I was requested to inoculate a young person, who was thought to have had the small-pox, but his parents were not quite certain; in one arm I introduced variolous matter, and in the other blood, taken as in experiment 3d.  On the second day after the operation, the punctured parts were inflamed, though I think the arm in which I had inserted variolous matter was rather more so than the other.  On the third the inflammation was increased, and looked much the same as in the preceding experiment. 4th.  The inflammation was much diminished, and on the 5th almost gone.  He was exposed at the same time to the natural infection, but has continued perfectly well.

“I have frequently observed (and believe most practitioners have done the same), that if variolous matter be inserted in the arm of a person who has previously had the small-pox, that the inflammation on the second or third days is much greater, than if they had not had the disease, but on the fourth or fifth it disappears.

“On the 23d I introduced blood into the arms of three more children, taken on the third and fourth days of the eruption.  The appearances were much the same as mentioned in experiments first and third.  They were afterwards inoculated with variolous matter, and had the disease in the regular way.