But all endings are also beginnings.
-- Narrator (The End)

Importance: The narrator establishes the structure and central theme of the novel through this line. This signifies that, though the novel is to begin at the end of Annie's life in a manner of speaking, it also serves as the beginning of her journey through heaven. But the line also points to the opportunity Annie acquires through the end of her life, as she is given a second lease on life once she wakes up from the coma.

Annie knows why he's leaving. Because she wanted that Creamsicle. That's why he's going away.
-- Annie (Annie Makes a Mistake #2)

Importance: This incident begins Annie's long habit of blaming herself for problems that arise in life. It is a central part of her personality, something that allows her to contend with the fact that she may not necessarily have control over certain events of her life. This habit also prevents Annie from seeing...