Transgenic Animals - Research Article from Macmillan Science Library: Genetics

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The term "transgenics" refers to the science of inserting a foreign gene into an organism's genome. Scientists do this, creating a "transgenic" organism, to study the function of the introduced gene and to identify genetic elements that determine which tissue and at what stage of an organism's development a gene is normally turned on. Transgenic animals have also been created to produce large quantities of useful proteins and to model human disease.

In the early 1980s Frank Ruddle and his colleagues created the first transgenic animal, a transgenic mouse. Researchers making transgenic mice use a very fine glass needle to inject pieces of DNA into a fertilized mouse egg. They inject the DNA into one of the egg's two pronuclei, before the pronuclei fuse to become the nucleus of the developing embryo's first cell. After the DNA is injected, multiple copies, usually joined end-to-end, insert randomly...

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This section contains 1,734 words
(approx. 6 pages at 300 words per page)
Buy the Transgenic Animals Encyclopedia Article
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Transgenic Animals from Macmillan. Copyright © 2001-2006 by Macmillan Reference USA, an imprint of the Gale Group. All rights reserved.
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