Multiple Alleles - Research Article from Macmillan Science Library: Genetics

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Examples of Multiple Alleles

Two human examples of multiple-allele genes are the gene of the ABO blood group system, and the human-leukocyte-associated antigen (HLA) genes.

The ABO system in humans is controlled by three alleles, usually referred to as IA, IB, and IO (the "I" stands for isohaemagglutinin). IA and IB are codominant and produce type A and type B antigens, respectively, which migrate to the surface of red blood cells, while IO is the recessive allele and produces no antigen. The blood groups arising from the different possible genotypes are summarized in the following table.

Genotype Blood Group
IA IA A
IA IO A
IB IB B
IB IO B
IA IB AB
IO IO O

HLA genes code for protein antigens that are expressed in most human cell...

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This section contains 610 words
(approx. 3 pages at 300 words per page)
Buy the Multiple Alleles Encyclopedia Article
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Macmillan Science Library: Genetics
Multiple Alleles from Macmillan Science Library: Genetics. Copyright © 2001-2006 by Macmillan Reference USA, an imprint of the Gale Group. All rights reserved.
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