Gene Discovery - Research Article from Macmillan Science Library: Genetics

This encyclopedia article consists of approximately 6 pages of information about Gene Discovery.
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Approaches for Identifying Genes

Candidate Gene Approach.

In the candidate gene approach, genes are selected based on their known or predicted biological function and on their hypothesized relation to the disease or trait. These genes are subject to mutation analysis to determine whether they are really involved. The problem with the candidate gene approach is that it relies on assumptions about the molecular mechanisms underlying the development of a trait. However, diseases are usually studied because little is known about their causes, so initial ideas about these "molecular mechanisms" often prove to be wrong.

In addition, the candidate gene approach can be very time consuming, and it has been successful only infrequently. Chromosomal abnormalities, such as deletions, inversions, or translocations, in individuals exhibiting a trait, as well as animal models mimicking the trait, are especially important for a candidate gene approach, since they provide clues to the genetic...

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This section contains 1,664 words
(approx. 6 pages at 300 words per page)
Buy the Gene Discovery Encyclopedia Article
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Macmillan Science Library: Genetics
Gene Discovery from Macmillan Science Library: Genetics. Copyright © 2001-2006 by Macmillan Reference USA, an imprint of the Gale Group. All rights reserved.
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