Diabetes - Research Article from Macmillan Science Library: Genetics

This encyclopedia article consists of approximately 6 pages of information about Diabetes.
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Type 1 Diabetes

Type 1 diabetes is caused by beta cell destruction, leading to insulin deficiency. T1DM was previously called insulin-dependent diabetes mellitus (IDDM), because patients who have it require insulin for survival. It was also called juvenile-onset diabetes mellitus, because most type 1 diabetics are children or young adults. At the time of diagnosis, about 85 percent to 90 percent of people with type 1 diabetes have antibodies directed against components of their beta cells, indicating that the immune system is responsible for the progressive and irreversible beta cell destruction.

Current evidence indicates a genetic component to T1DM. HLA (histocompatibility leukocyte antigen) genes are a group of genes on chromosome 6 that encode proteins that are part of the immune system. Normally the immune system defends the body against disease by destroying foreign cells, but in the case of type 1 diabetes, the body's immune system destroys its own beta cells.

Certain types of...

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This section contains 1,730 words
(approx. 6 pages at 300 words per page)
Buy the Diabetes Encyclopedia Article
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Macmillan Science Library: Genetics
Diabetes from Macmillan Science Library: Genetics. Copyright © 2001-2006 by Macmillan Reference USA, an imprint of the Gale Group. All rights reserved.
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