The Wall Drug Store, located in Wall, South Dakota, is probably the most unusual drug store in the world. Since 1936, it has been a popular tourist attraction in the American heartland. Wall Drug is known for many unlikely things, including signs all over the world in places like Moscow, Russia, and Paris, France, proclaiming the distance to Wall Drug in South Dakota. There is even a sign pounded into the ice at the South Pole reading "Wall Drug, Free Ice Water, 9,333 Miles." Why all the fuss about a drug store in the middle of nowhere? Because Wall Drug has become one of the world's biggest "in-jokes."

Wall Drug, in tiny Wall, South Dakota, is famous for being so tacky and unhip that it is actually cool. Courtesy of Wall Drug Store.

Wall Drug is certainly the only reason most people ever visit the dusty town of...