What is the main conflict in The Queen of the Damned by Anne Rice?

The Queen of the Damned is the third of Anne Rice's Vampire Chronicles. This fictional story is told in five parts. It chronicles the trials of a group of modern-day vampires locked in struggle to save the mortal humans from the first vampire, Akasha, who has awoken from six-thousand years of sleep with a plan to kill all the males on earth in order to usher in a reign of peace. Akasha has taken the mischievous vampire, Lestat, as her immortal lover. She's also destroyed all other vampires, except for a few of Lestat's close friends. In the end, the fulfillment of an ancient curse destroys Akasha, saves the mortals, and reunites Lestat with his loved ones.