The following sections of this BookRags Literature Study Guide is offprint from Gale's For Students Series: Presenting Analysis, Context, and Criticism on Commonly Studied Works: Introduction, Author Biography, Plot Summary, Characters, Themes, Style, Historical Context, Critical Overview, Criticism and Critical Essays, Media Adaptations, Topics for Further Study, Compare & Contrast, What Do I Read Next?, For Further Study, and Sources.
(c)1998-2002; (c)2002 by Gale. Gale is an imprint of The Gale Group, Inc., a division of Thomson Learning, Inc. Gale and Design and Thomson Learning are trademarks used herein under license.
The following sections, if they exist, are offprint from Beacham's Encyclopedia of Popular Fiction: "Social Concerns", "Thematic Overview", "Techniques", "Literary Precedents", "Key Questions", "Related Titles", "Adaptations", "Related Web Sites". (c)1994-2005, by Walton Beacham.
The following sections, if they exist, are offprint from Beacham's Guide to Literature for Young Adults: "About the Author", "Overview", "Setting", "Literary Qualities", "Social Sensitivity", "Topics for Discussion", "Ideas for Reports and Papers". (c)1994-2005, by Walton Beacham.
All other sections in this Literature Study Guide are owned and copyrighted by BookRags, Inc.
Recombination, is a process during which genetic material is shuffled during reproduction to form new combinations. This mixing is an important from an evolutionary standpoint because it allows the expression of different traits between generations. The process involves a physical exchange of nucleotides between duplicate strands of deoxyribonucleic acid (DNA).
There are three types of recombination; homologous recombination, specific recombination and transposition. Each type occurs under different circumstances. Homologous recombination occurs in eukaryotes, typically during the first phase of the meiotic cell division cycle. In most eukaryotic cells, genetic material is organized as chromosomes in the nucleus. A nick is made on the chromosomal DNA of corresponding strands and the broken strands cross over, or exchange, with each other. The recombinant region is extended until a whole gene is transferred. At this point, further recombination can occur or it can be stopped. Both processes require the creation of another break in the DNA strand and subsequent sealing of the nicks by special enzymes.
Site specific recombination typically occurs in prokaryotes. It is the mechanism by which viral genetic material is incorporated into bacterial chromosomes. The event is site-specific, as the incorporation (integration) of viral genetic material occurs at a specific location on the bacterial genome, called the attachment site, which is homologous with the phage genome. Under appropriate conditions alignment and merging of the viral and bacterial genomes occurs.
Transposition is a third type of recombination. It involves transposable elements called transposons. These are short segments of DNA found in both prokaryotes and eukaryotes, which contain the information enabling their movement from one genome to another, as well as genes encoding other functions. The movement of a transposon, a process of transposition, is initiated when an enzyme cuts DNA at a target site. This leaves a section that has unpaired nucleotides. Another enzyme called transposase facilitates insertion of the transposon at this site. Transposition is important in genetic engineering, as other genes can be relocated along with the transposon DNA. As well, transposition is of natural significance. For example, the rapid reshuffling of genetic information possible with transposition enables immunocytes to manufacture the millions of different antibodies required to protect eukaryotes from infection.