The following sections of this BookRags Literature Study Guide is offprint from Gale's For Students Series: Presenting Analysis, Context, and Criticism on Commonly Studied Works: Introduction, Author Biography, Plot Summary, Characters, Themes, Style, Historical Context, Critical Overview, Criticism and Critical Essays, Media Adaptations, Topics for Further Study, Compare & Contrast, What Do I Read Next?, For Further Study, and Sources.
(c)1998-2002; (c)2002 by Gale. Gale is an imprint of The Gale Group, Inc., a division of Thomson Learning, Inc. Gale and Design and Thomson Learning are trademarks used herein under license.
The following sections, if they exist, are offprint from Beacham's Encyclopedia of Popular Fiction: "Social Concerns", "Thematic Overview", "Techniques", "Literary Precedents", "Key Questions", "Related Titles", "Adaptations", "Related Web Sites". (c)1994-2005, by Walton Beacham.
The following sections, if they exist, are offprint from Beacham's Guide to Literature for Young Adults: "About the Author", "Overview", "Setting", "Literary Qualities", "Social Sensitivity", "Topics for Discussion", "Ideas for Reports and Papers". (c)1994-2005, by Walton Beacham.
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The operator is a regulatory region that controls the transcription of gene(s) located downstream.
The operator typically is located between the gene(s) it controls and the region of the DNA where the initiator of transcription, RNA polymerase, binds. When a repressor protein occupies the operator, the RNA polymerase is physically prevented from moving along the DNA and producing the messenger RNA (mRNA). When the repressor protein is detached from the operator, the polymerase is free to move and mRNA production, and ultimately, protein production, commences.
Typically, the operator is located just upstream of the genes it controls. This location allows RNA polymerase to bind to the DNA, but, if the operator is occupied, for the initiation of transcription to remain blocked. Once the operator is free, however, polymerase movement, and hence transcription, can commence immediately. The genetic system is thus primed for rapid activity.
In bacteria, several genes may be controlled simultaneously by the region to which the polymerase binds and one or more operators. When under such multiple control, the entire system is called an operon. The best-studied operon is the lac operon of Escherichia coli.