The following sections of this BookRags Literature Study Guide is offprint from Gale's For Students Series: Presenting Analysis, Context, and Criticism on Commonly Studied Works: Introduction, Author Biography, Plot Summary, Characters, Themes, Style, Historical Context, Critical Overview, Criticism and Critical Essays, Media Adaptations, Topics for Further Study, Compare & Contrast, What Do I Read Next?, For Further Study, and Sources.
(c)1998-2002; (c)2002 by Gale. Gale is an imprint of The Gale Group, Inc., a division of Thomson Learning, Inc. Gale and Design and Thomson Learning are trademarks used herein under license.
The following sections, if they exist, are offprint from Beacham's Encyclopedia of Popular Fiction: "Social Concerns", "Thematic Overview", "Techniques", "Literary Precedents", "Key Questions", "Related Titles", "Adaptations", "Related Web Sites". (c)1994-2005, by Walton Beacham.
The following sections, if they exist, are offprint from Beacham's Guide to Literature for Young Adults: "About the Author", "Overview", "Setting", "Literary Qualities", "Social Sensitivity", "Topics for Discussion", "Ideas for Reports and Papers". (c)1994-2005, by Walton Beacham.
All other sections in this Literature Study Guide are owned and copyrighted by BookRags, Inc.
Bilirubin is the waste product that results from the breakdown of hemoglobin molecules in red blood cells. It is excreted from the body via the bile ducts of the liver, typically as the main component of bile.
Bilirubin is an end product of the metabolism of the heme component of red blood cells. In our bodies, bilirubin serves an important purpose. It is one of the most powerful anti-oxidants produced by the body (vitamins E and C are other examples of anti-oxidants). An anti-oxidant functions, as the name implies, to prevent the chemical process of oxidation, which can be destructive to the functioning of cells, tissues and organs. In normal quantities, bilirubin aids the body. But, when it accumulates, bilirubin poses problems.
Accumulation of bilirubin can occur in several ways. A liver malfunction can result in the impaired or blocked excretion of bilirubin. Secondly, the compound can be over-produced. Lastly, the normal binding of bilirubin to another molecule in body fluids, albumin, may be impaired, allowing more of the unbound form of bilirubin to be present. It is this unbound form that is problematic.
The build-up of bilirubin in the fatty tissues of the skin turns the tissues yellow. This condition is known as jaundice. Excessive accumulation of bilirubin in newborns may be serious if untreated, causing permanent brain damage. In this condition, kernicterus, a decrease in pH causes bilirubin to come out of solution and accumulate in solid form in the brain. The brain malfunction can lead to a characteristic form of crippling called athetoid cerebral palsy. To prevent these catastrophes, bilirubin levels are monitored in newborns. Excessive levels can be treated in two ways. A newborn can be exposed to a "bilirubin light", which emits light of a certain wavelength in order to slightly alter the three-dimensional shape of the bilirubin molecule so that it is able to dissolve back into solution again. The dissolved bilirubin is then able to be excreted form the body more readily. Another treatment procedure called exchange transfusion washes out excess bilirubin by a series of transfusions. In each transfusion a small amount of the baby's blood is removed and replaced with an equal volume of adult donor blood (not the mother's, to avoid antigenic reaction) that is the same type as the mother's blood.