[Illustration:  FIG. 96.—­Tuberculous Elephantiasis in a woman aet. 35.]

On parts of the body other than the face, the disease is even more chronic, and is often attended with a considerable production of dense fibrous tissue—­the so-called fibroid lupus.  Sometimes there is a warty thickening of the epidermis—­lupus verrucosus.  In the fingers and toes it may lead to a progressive destruction of tissue like that observed in leprosy, and from the resulting loss of portions of the digits it has been called lupus mutilans.  In the lower extremity a remarkable form of the disease is sometimes met with, to which the term lupus elephantiasis (Fig. 96) has been applied.  It commences as an ordinary lupus of the toes or dorsum of the foot, from which the tuberculous infection spreads to the lymph vessels, and the limb as a whole becomes enormously swollen and unshapely.

Finally, a long-standing lupus, especially on the cheek, may become the seat of epithelioma—­lupus epithelioma—­usually of the exuberant or cauliflower type, which, like other epitheliomas that originate in scar tissue, presents little tendency to infect the lymphatics.

The diagnosis of lupus is founded on the chronic progress and long duration, and the central scarring with peripheral extension of the disease.  On the face it is most liable to be confused with syphilis and with rodent cancer.  The syphilitic lesion belongs to the tertiary period, and although presenting a superficial resemblance to tuberculosis, its progress is more rapid, so that within a few months it may involve an area of skin as wide as would be affected by lupus in as many years.  Further, it readily yields to anti-syphilitic treatment.  In cases of tertiary syphilis in which the nose is destroyed, it will be noticed that the bones have suffered most, while in lupus the destruction of tissue involves chiefly the soft parts.

Rodent cancer is liable to be mistaken for lupus, because it affects the same parts of the face; it is equally chronic, and may partly heal.  It begins later in life, however, the margin of the ulcer is more sharply defined, and often presents a “rolled” appearance.

Treatment.—­When the disease is confined to a limited area, the most rapid and certain cure is obtained by excision; larger areas are scraped with the sharp spoon.  The ray treatment includes the use of luminous, Rontgen, or radium rays, and possesses the advantage of being comparatively painless and of being followed by the least amount of scarring and deformity.

Encouraging results have also been obtained by the application of carbon dioxide snow.

#Multiple subcutaneous tuberculous nodules# are met with chiefly in children.  They are indolent and painless, and rarely attract attention until they break down and form abscesses, which are usually about the size of a cherry, and when these burst sinuses or ulcers result.  If the overlying skin is still intact, the best treatment is excision.  If the abscess has already infected the skin, each focus should be scraped and packed.