There is evidence that the tendency to bleed is greater at certain times than at others—­in some cases showing almost a cyclical character—­although nothing is known as to the cause of the variation.

After a severe haemorrhage into the cellular tissue or into a joint, the patient becomes pale and anaemic, the temperature may rise to 102 or 103 F., the pulse become small and rapid, and haemic murmurs are sometimes developed over the heart and large arteries.  The swelling is tense, fluctuating, and hot, and there is considerable pain and tenderness.

In exceptional cases, blisters form over the seat of the effusion, or the skin may even slough, and the clinical features may therefore come to simulate closely those of an acute suppurative condition.  When the skin sloughs, an ulcer is formed with altered blood-clot in its floor like that seen in scurvy, and there is a remarkable absence of any attempt at healing.

The acute symptoms gradually subside, and the blood is slowly absorbed, the discoloration of the skin passing through the same series of changes as occur after an ordinary bruise.  The patients seldom manifest the symptoms of the bloodless state, and the blood is rapidly regenerated.

The diagnosis is easy if the patient or his friends are aware of the family tendency to haemorrhage and inform the doctor of it, but they are often sensitive and reticent regarding the fact, and it may only be elicited after close investigation.  From the history it is usually easy to exclude scurvy and purpura.  Repeated haemorrhages into a joint may result in appearances which closely simulate those of tuberculous disease.  Recent haemorrhages into the cellular tissue often present clinical features closely resembling those of acute cellulitis or osteomyelitis.  A careful examination, however, may reveal ecchymoses on other parts of the body which give a clue to the nature of the condition, and may prevent the disastrous consequences that may follow incision.

These patients usually succumb sooner or later to haemorrhage, although they often survive several severe attacks.  After middle life the tendency to bleed appears to diminish.

Treatment.—­As a rule the ordinary means of arresting haemorrhage are of little avail.  From among the numerous means suggested, the following may be mentioned:  The application to the bleeding point of gauze soaked in a 1 in 1000 solution of adrenalin; prolonged inhalation of oxygen; freezing the part with a spray of ethyl-chloride; one or more subcutaneous injections of gelatin—­5 ounces of a 2.5 per cent. solution of white gelatin in normal salt solution being injected at a temperature of about 100 F.; the injection of pituitary extract.  The application of a pad of gauze soaked in the blood of a normal person sometimes arrests the bleeding.