Diagnosis of Secondary Syphilis.—­A routine examination should be made of the parts of the body which are most often affected in this disease—­the scalp, mouth, throat, posterior cervical glands, and the trunk, the patient being stripped and examined by daylight.  Among the diagnostic features of the skin affections the following may be mentioned:  They are frequently, and sometimes to a marked degree, symmetrical; more than one type of eruption—­papules and pustules, for example—­are present at the same time; there is little itching; they are at first a dull-red colour, but later present a brown pigmentation which has been likened to the colour of raw ham; they exhibit a predilection for those parts of the forehead and neck which are close to the roots of the hair; they tend to pass off spontaneously; and they disappear rapidly under treatment.

#Serum Diagnosis—­Wassermann Reaction.#—­Wassermann found that if an extract of syphilitic liver rich in spirochaetes is mixed with the serum from a syphilitic patient, a large amount of complement is fixed.  The application of the test is highly complicated and can only be carried out by an expert pathologist.  For the purpose he is supplied with from 5 c.c. to 10 c.c. of the patient’s blood, withdrawn under aseptic conditions from the median basilic vein by means of a serum syringe, and transferred to a clean and dry glass tube.  There is abundant evidence that the Wassermann test is a reliable means of establishing a diagnosis of syphilis.

A definitely positive reaction can usually be obtained between the fifteenth and thirtieth day after the appearance of the primary lesion, and as time goes on it becomes more marked.  During the secondary period the reaction is practically always positive.  In the tertiary stage also it is positive except in so far as it is modified by the results of treatment.  In para-syphilitic lesions such as general paralysis and tabes a positive reaction is almost always present.  In inherited syphilis the reaction is positive in every case.  A positive reaction may be present in other diseases, for example, frambesia, trypanosomiasis, and leprosy.

As the presence of the reaction is an evidence of the activity of the spirochaetes, repeated applications of the test furnish a valuable means of estimating the efficacy of treatment.  The object aimed at is to change a persistently positive reaction to a permanently negative one.

#Treatment of Syphilis.#—­In the treatment of syphilis the two main objects are to maintain the general health at the highest possible standard, and to introduce into the system therapeutic agents which will inhibit or destroy the invading parasite.