The third and fourth Beasts of Daniel are the same with the Dragon and ten-horned Beast of John, but with this difference:  John puts the Dragon for the whole Roman Empire while it continued entire, because it was entire when that Prophecy was given; and the Beast he considers not till the Empire became divided:  and then he puts the Dragon for the Empire of the Greeks, and the Beast for the Empire of the Latins.  Hence it is that the Dragon and Beast have common heads and common horns:  but the Dragon hath crowns only upon his heads, and the Beast only upon his horns; because the Beast and his horns reigned not before they were divided from the Dragon:  and when the Dragon gave the Beast his throne, the ten horns received power as Kings, the same hour with the Beast.  The heads are seven successive Kings.  Four of them were the four horsemen which appeared at the opening of the first four seals.  In the latter end of the sixth head, or seal, considered as present in the visions, it is said, five of the seven Kings are fallen, and one is, and another is not yet come; and the Beast that was and is not, being wounded to death with a sword, he is the eighth, and of the seven:  he was therefore a collateral part of the seventh.  The horns are the same with those of Daniel’s fourth Beast, described above.

The four horsemen which appear at the opening of the first four seals, have been well explained by Mr. Mede; excepting that I had rather continue the third to the end of the reign of the three Gordians and Philip the Arabian, those being Kings from the South, and begin the fourth with the reign of Decius, and continue it till the reign of Dioclesian.  For the fourth horseman sat upon a pale horse, and his name was Death; and hell followed with him; and power was given them to kill unto the fourth part of the earth, with the sword, and with famine, and with the plague, and with the Beasts of the earth, or armies of invaders and rebels:  and as such were the times during all this interval.  Hitherto the Roman Empire continued in an undivided monarchical form, except rebellions; and such it is represented by the four horsemen.  But Dioclesian divided it between himself and Maximianus, A.C. 285; and it continued in that divided state, till the victory of Constantine the great over Licinius, A.C. 323, which put an end to the heathen persecutions set on foot by Dioclesian and Maximianus, and described at the opening of the fifth seal.  But this division of the Empire was imperfect, the whole being still under one and the same Senate.  The same victory of Constantine over Licinius a heathen persecutor, began the fall of the heathen Empire, described at the opening of the sixth seal:  and the visions of this seal continue till after the reign of Julian the Apostate, he being a heathen Emperor, and reigning over the whole Roman Empire.