There is a disease, which frequently affects children in the cradle, which is termed ecstasy, and seems to consist in certain exertions to relieve painful sensation, in which the voluntary power is not so far excited as totally to awaken them, and yet is sufficient to remove the disagreeable sensation, which excites it; in this case changing the posture of the child frequently relieves it.

I have at this time under my care an elegant young man about twenty-two years of age, who seldom sleeps more than an hour without experiencing a convulsion fit; which ceases in about half a minute without any subsequent stupor.  Large doses of opium only prevented the paroxysms, so long as they prevented him from sleeping by the intoxication, which they induced.  Other medicines had no effect on him.  He was gently awakened every half hour for one night, but without good effect, as he soon slept again, and the fit returned at about the same periods of time, for the accumulated sensorial power, which occasioned the increased sensibility to pain, was not thus exhausted.  This case evinces, that the sensibility of the system to internal excitation increases, as our sleep is prolonged; till the pain thus occasioned produces voluntary exertion; which, when it is in its usual degree, only awakens us; but when it is more violent, it occasions convulsions.

The cramp in the calf of the leg is another kind of convulsion, which generally commences in sleep, occasioned by the continual increase of irritability from internal stimuli, or of sensibility, during that state of our existence.  The cramp is a violent exertion to relieve pain, generally either of the skin from cold, or of the bowels, as in some diarrhoeas, or from the muscles having been previously overstretched, as in walking up or down steep hills.  But in these convulsions of the muscles, which form the calf of the leg, the contraction is so violent as to occasion another pain in consequence of their own too violent contraction; as soon as the original pain, which caused the contraction, is removed.  And hence the cramp, or spasm, of these muscles is continued without intermission by this new pain, unlike the alternate convulsions and remissions in epileptic fits.  The reason, that the contraction of these muscles of the calf of the leg is more violent during their convulsion than that of others, depends on the weakness of their antagonist muscles; for after these have been contracted in their usual action, as at every step in walking, they are again extended, not, as most other muscles are, by their antagonists, but by the weight of the whole body on the balls of the toes; and that weight applied to great mechanical advantage on the heel, that is, on the other end of the bone of the foot, which thus acts as a lever.

Another disease, the periods of which generally commence during our sleep, is the asthma.  Whatever may be the remote cause of paroxysms of asthma, the immediate cause of the convulsive respiration, whether in the common asthma, or in what is termed the convulsive asthma, which are perhaps only different degrees of the same disease, must be owing to violent voluntary exertions to relieve pain, as in other convulsions; and the increase of irritability to internal stimuli, or of sensibility, during sleep must occasion them to commence at this time.