desolate, v. devastate, depredate, despoil, sack, lay waste.

despair, n. hopelessness, desperation, inconsolableness.

desperate, a. irretrievable, hopeless, incurable, remediless, outrageous, atrocious, monstrous, heinous.

desperation, n. despair, hopelessness, recklessness.

despicable, a. contemptible, abject.

despise, v. contemn, disdain.

despiteful, a. malicious, spiteful, resentful.

despondency, n. melancholy, depression, dejection.

despondent, a. disheartened, discouraged, dejected, depressed.

despot, n. tyrant, autocrat.

despotic, a. autocratic, tyrannical, absolute, despotical.

despotism, n. absolutism, autocracy, tyranny.

destine, v. doom, preordain, appoint, foredoom.

destiny, n. fate, doom, lot, fortune.

destitute, a. devoid, deficient, lacking; needy, very poor.

destitution, n. privation, need, want, poverty, deficiency, indigence.

destroy, v. annihilate, undo, demolish, raze, desolate, devour, sack, dismantle, eradicate, exterminate, ruin.  Antonyms:  conserve, preserve, perpetuate, spare.

destroyer, n. iconoclast, annihilator, vandal, hun, destructionist, Apollyon.

destruction, n. annihilation, demolition, eradication, ruin, perdition, havoc, vandalism, subversion, desolation, devastation, iconoclasm.  Antonyms:  conservation preservation, perpetuation.

destructive, a. ruinous, iconoclastic, vandal, vandalic, internecine, deleterious, pernicious, annihilative.

desultory, a. fitful, irregular, cursory, unsystematic.

detach, v. disconnect, disjoin, sever, disunite, isolate, segregate.

detachment, n. disconnection, separation, disunion, isolation, segregation.

detail, v. particularize, enumerate.

details, n. pl. minutiae, particulars.

detention, n. restraint, custody, confinement, arrest.

deter, v. hinder, prevent, dissuade, restrain.

deteriorate, v. decline, degenerate, retrograde; corrupt, vitiate, debase, degrade.

deterioration, n. decline, degeneration, retrogression; vitiation, corruption, debasement.

detest, v. loathe, despise, abominate, abhor, hate, execrate.

detestable, a. abominable, loathsome, execrable, abhorrent.

detestation, n. abomination, execration, loathing, abhorrence, antipathy.

deuced, a. (Low) devilish, excessive, extreme.

devastate, v. desolate, sack, despoil, ravage, plunder.

devastation, n. desolation, sacking, despoliation, ravage, havoc.

develop, v. mature, evolve; unfold, disentangle, unravel.  Antonyms:  atrophy, blast, blight.

development, n. unfoldment, progression, evolution; hypertrophy (excessive development).  Antonyms:  atrophy, undevelopment, abortion, embryo.

deviate, v. swerve, deflect, digress, stray, wander, diverge.  Antonym:  continue.