William Kennedy may refer to:
- William Nassau Kennedy, second Mayor of Winnipeg, Manitoba, Canada
- William Kennedy (author), the Pulitzer Prize-winning author of Ironweed
- William Kennedy (politician), the early-nineteenth-century United States congressman from North Carolina in the Democratic-Republican Party
- William Kennedy (captain), (1814-1890) the Canadian captain and explorer.
- William Hew Clark-Kennedy, (1879-1961), the Canadian serviceman and recipient of the Victoria Cross
- William Kennedy (Connecticut), (1768-1834), United States congressman from Connecticut
- William Kennedy III, president and CEO of the North Carolina Mutual Insurance Company until 1990.
- William Costello Kennedy, (1868-1923), Canadian businessman and politician
- Billy Kennedy, of the Australian soap opera Neighbours
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