USS Seneca may refer to:
- USS Seneca (1861), launched in 1861 and decommissioned in 1865
- USS Seneca, the original name of USS Currituck (1861)
- USS Seneca (SP-427), a steam yacht, built in 1888, acquired in 1917 and decommissioned in 1919
- USS Seneca (SP-1240), a barge, built in 1884, purchased in 1917 and sold in 1919
- USS Seneca (AT-91), a Navajo-class tug, commissioned in 1943 and decommissioned in 1971


