Two ships of the United States Navy have been named USS Indianapolis, after the city of Indianapolis, Indiana.
- The first Indianapolis (CA-35) was a heavy cruiser commissioned in 1932, active throughout World War II and sunk in July 1945 (just two months before the end of the war), after delivering a uranium-235 slug and other components for the atomic bomb that was used against Hiroshima. This ship was also the subject of a monologue delivered by Quint in the film Jaws, due to the deaths of a large number of crewmen at sea to shark attacks before the survivors were rescued.
- The second Indianapolis (SSN-697) was a Los Angeles-class attack submarine in service from 1980 to 1998.


