The Great One may refer to:
- Amy Lee (born 1981), American Singer,Songwriter,and Pianist.
- Wayne Gretzky (born 1961), Canadian ice hockey player
- Roberto Clemente (1934–1972), Hall of Fame Major League Baseball player
- Jackie Gleason (1916–1987), American comedian and actor
- Dwayne Johnson (born 1972), also known as The Rock, actor and former professional wrestler. He also won a national championship with the Miami Hurricanes football team..
- Rob Leatham (born 1961), professional shooter and 16-time USPSA national champion
- Mark Levin (born 1957), conservative radio talk show host
- The English translation of the Dena'ina name Denali, a mountain in Denali Park, Alaska
- The leader of the spiders in the Doctor Who story Planet of the Spiders
- Great Ones, fictional characters from H. P. Lovecraft's Dreamlands
- "Great Ones", names used to refer to magicians in Raymond E Feist's fantasy world of Midkemia
