TSR may mean:
- BAC TSR-2, a prototype British bomber
- Full Metal Panic!: The Second Raid, an anime
- Tamaracouta Scout Reserve, a Scout camp in Quebec
- Technical Service Request
- Technically Specified Rubber, a form of rubber
- Telemarketing Sales Rule
- Technical Support Representative
- Telephone Service Representative
- Télévision Suisse Romande, a French language Swiss TV channel
- Terminate and Stay Resident, utility programs used in MS-DOS
- That's So Raven, an American TV show
- The Shadow Rising, the fourth book in American author Robert Jordan's fantasy series The Wheel of Time
- Thermochemical sulfate reduction, a process of chemical reduction of sulfate in sulfide occurring at elevated temperature, e.g. in an oil field and important for organic matter maturation
- The Sports Reporters, an American sports talk show
- The Stone Roses, a rock band from Manchester
- The Strategic Review, a magazine published by TSR, Inc in the 1970s
- The Student Room, a United Kingdom-based internet forum
- Tip speed ratio, a measurement used for wind turbines
- Torque Speed Relationship
- Total Shareholder Return, a concept used to compare the performance of different companies’ shares
- Timişoara "Traian Vuia" International Airport
- Tropical Storm Risk
- True Symphonic Rockestra
- TSR Records, a record label
- TSR, Inc. (originally Tactical Studies Rules) was the publisher that originally released the Dungeons & Dragons role-playing game
- TSR I and II, prototypes of the Fairey Swordfish torpedo bomber
- The Spriters' Resource, a website with large collections of video game sprites
- Travelling Stock Reserve
