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TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)
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| PDB rendering based on 1fvr. | ||||||||||||||
| Available structures: 1fvr, 2gy5, 2gy7, 2oo8, 2osc, 2p4i | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | TEK; CD202B; TIE-2; TIE2; VMCM; VMCM1 | |||||||||||||
| External IDs | OMIM: 600221 MGI: 98664 Homologene: 397 | |||||||||||||
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| RNA expression pattern | ||||||||||||||
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| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 7010 | 21687 | ||||||||||||
| Ensembl | ENSG00000120156 | ENSMUSG00000006386 | ||||||||||||
| Uniprot | Q02763 | Q02858 | ||||||||||||
| Refseq | NM_000459 (mRNA) NP_000450 (protein) |
NM_013690 (mRNA) NP_038718 (protein) |
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| Location | Chr 9: 27.1 - 27.22 Mb | Chr 4: 94.23 - 94.37 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal), also known as TEK, is a human gene.
The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.[1]
References
Further reading
- Partanen J, Armstrong E, Mäkelä TP, et al. (1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains.". Mol. Cell. Biol. 12 (4): 1698-707. PMID 1312667.
- Huang L, Turck CW, Rao P, Peters KG (1995). "GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase.". Oncogene 11 (10): 2097-103. PMID 7478529.
- Deans JP, Kalt L, Ledbetter JA, et al. (1995). "Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20.". J. Biol. Chem. 270 (38): 22632-8. PMID 7545683.
- Gallione CJ, Pasyk KA, Boon LM, et al. (1995). "A gene for familial venous malformations maps to chromosome 9p in a second large kindred.". J. Med. Genet. 32 (3): 197-9. PMID 7783168.
- Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42-50. doi:10.1006/geno.1994.1457. PMID 7829101.
- Boon LM, Mulliken JB, Vikkula M, et al. (1995). "Assignment of a locus for dominantly inherited venous malformations to chromosome 9p.". Hum. Mol. Genet. 3 (9): 1583-7. PMID 7833915.
- Dumont DJ, Anderson L, Breitman ML, Duncan AM (1995). "Assignment of the endothelial-specific protein receptor tyrosine kinase gene (TEK) to human chromosome 9p21.". Genomics 23 (2): 512-3. doi:10.1006/geno.1994.1536. PMID 7835909.
- Ziegler SF, Bird TA, Schneringer JA, et al. (1993). "Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta.". Oncogene 8 (3): 663-70. PMID 8382358.
- Davis S, Aldrich TH, Jones PF, et al. (1997). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.". Cell 87 (7): 1161-9. PMID 8980223.
- Suri C, Jones PF, Patan S, et al. (1997). "Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.". Cell 87 (7): 1171-80. PMID 8980224.
- Vikkula M, Boon LM, Carraway KL, et al. (1997). "Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2.". Cell 87 (7): 1181-90. PMID 8980225.
- Witzenbichler B, Maisonpierre PC, Jones P, et al. (1998). "Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2.". J. Biol. Chem. 273 (29): 18514-21. PMID 9660821.
- Asahara T, Chen D, Takahashi T, et al. (1998). "Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization.". Circ. Res. 83 (3): 233-40. PMID 9710115.
- Sato A, Iwama A, Takakura N, et al. (1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells.". Int. Immunol. 10 (8): 1217-27. PMID 9723709.
- Jones N, Dumont DJ (1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R.". Oncogene 17 (9): 1097-108. doi:10.1038/sj.onc.1202115. PMID 9764820.
- De Sepulveda P, Okkenhaug K, Rose JL, et al. (1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.". EMBO J. 18 (4): 904-15. doi:10.1093/emboj/18.4.904. PMID 10022833.
- Valenzuela DM, Griffiths JA, Rojas J, et al. (1999). "Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1904-9. PMID 10051567.
- Calvert JT, Riney TJ, Kontos CD, et al. (1999). "Allelic and locus heterogeneity in inherited venous malformations.". Hum. Mol. Genet. 8 (7): 1279-89. PMID 10369874.
- Jones N, Master Z, Jones J, et al. (1999). "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.". J. Biol. Chem. 274 (43): 30896-905. PMID 10521483.
- Fachinger G, Deutsch U, Risau W (1999). "Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2.". Oncogene 18 (43): 5948-53. doi:10.1038/sj.onc.1202992. PMID 10557082.
