Syracuse may refer to: Large cities:
- Syracuse, New York, in the United States
- Syracuse, Sicily, within the Province of Syracuse, in Italy
Small cities and other municipalities in the United States:
- Syracuse, Indiana
- Syracuse, Kansas
- Syracuse, Missouri
- Syracuse, Nebraska
- Syracuse, Ohio
- Syracuse, Utah
- Syracuse, South Carolina
Suburbs of Syracuse, New York:
Syracuse may also refer to:
- Syracuse University, in Syracuse, New York or its sports teams, known as the Syracuse Orange
- Syracuse problem, a famous unsolved problem in mathematics
