The following people or characters have the given name Spike:
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Real people
- Spike, a newcomer Romanian rapper promoted by Parazitii
- Spike Lee, a filmmaker
- Spike Jonze, a filmmaker
- Spike Jones, a satirist
- Spike Milligan, a satirist
- Spike Robinson, a jazz musician
- Spike Slawson, a punk vocalist and bassist of the Swinging Utters and Me First and the Gimme Gimmes
- Matt Hyson (aka Spike Dudley), former professional wrestler
- Spike (porn star), a gay pornography actor
- Spike Feresten, television writer and talk show host
- Spike Xavier, Lead Singer of Nu-Metal band Corporate Avenger
- Spike, a Welsh musician, co-founder of Z Block Records, Reptile Ranch and Weekend
- Sp!ke (German Beatboxer), last seen in Stern TV
Fictional characters
People
- Spike, a main playable character in the Ape Escape video game series
- Spike Spiegel, from the Japanese anime Cowboy Bebop
- Spike (Buffyverse), a vampire
- Spike, Fonzie's cousin in Happy Days
- Spike Fumo, in Spike of Bensonhurst
- Christine "Spike" Nelson, in the Degrassi series
- Spike Thomson, in Press Gang
- Spike, a member of the Screws Gang in Medabots
- Spike Lester, a character on the soap opera Passions
- The Spike (Marvel Comics), a member of the X-Statix
- Spike Freeman, another character in Marvel Comics' X-Statix/X-Force
- Spike (The Land Before Time), a young stegosaurus in The Land Before Time film series
- "Spike" Stoker, a supporting character from Jasper Fforde's Thursday Next books
- Joshua "Spike" Cohen, a Jew from Tom Robbins' novel Skinny Legs and All.
- Spike, a character originating in Super Mario Bros. 3 who launches spiked mace balls at you
- Spike, the boss of the Midday Gardens world in the "Spyro: Year of the Dragon" video game
- Spike, a character in the DC Comics comic book Sugar and Spike
- Spike Lavery, a character on All My Children, he is the son of Ryan Lavery and Kendall Hart.
- Father Spike, a high-church parish priest who is mentioned in CS Lewis' book The Screwtape Letters
- Spike, Roger Wilco's alien pet in Space Quest V: The Next Mutation
- Spike, a porcupine from the movie Over the Hedge (film)
- Spike Witwicky, a character from the Transformers TV cartoon series and comic books.
- Spike (NX Files), a fictional character in an action adventure web-show called NX Files.
- Spike (Hollyoaks), a character in the UK soap opera.
Dogs
- Spike (Peanuts), Snoopy's brother in Peanuts
- Spike (Tom and Jerry), Tom's nemesis in the cartoon series Tom and Jerry
- Spike the Bulldog and Chester the Terrier, in the Warner Bros. Looney Tunes and Merrie Melodies series of cartoons
- Spike, the family pet in Rugrats
- Spike, Heathcliff's nemesis in the comic strip and animated series Heathcliff
- Spike, Droopy's nemesis in Tex Avery's Droopy Dog theatrical cartoon series
