Spalding High School can refer to:
- Spalding High School (Georgia) in Griffin, Georgia
- Spalding High School (Illinois) in Chicago, Illinois
- Spalding Institute, later Academy of Our Lady-Spalding Institute, now consolidated as Peoria Notre Dame High School in Peoria, Illinois
- Spalding High School (Nebraska) in Spalding, Nebraska
- Spalding High School (United Kingdom) in Lincolnshire, United Kingdom
- Archbishop Spalding High School in Severn, Maryland
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