A shire is an administrative district in the United Kingdom and Australia. Shire may also refer to one of these geographical features:
- Shire River, a river draining Lake Malawi, and a major tributary of the Zambezi, in Malawi and Mozambique
- Shire Highlands, a plateau in southern Malawi lying east of the Shire River
- Shire, Ethiopia, a town in Ethiopia also known as Inda Selassie
- The Shire is an informal name to Shropshire, a county in the United Kingdom
- Shire (Middle-earth), a region in J. R. R. Tolkien's Middle-earth legendarium
- Sutherland Shire in Sydney, Australia
Shire or Shires may also mean:
- Shire plc, a British specialty pharmaceuticals company
- Shire horse, a large breed of draft horse
- Talia Shire, an American actress
- The Shires, a shopping centre in Leicester, UK
- Mohamoud Ali Shire (1897–1960), Sultan of Warsengeli (Somalia)
- Barre Adan Shire Hiiraale, Somali Minister of Defense and leader of the Juba Valley Alliance
- East Stirlingshire F.C., Scottish football club nicknamed "The Shire"
