The Seneca River is created by the confluence of the Keowee River and the Little River in northern South Carolina, just downriver from Lake Keowee. The Seneca River flows from the confluence into Lake Hartwell, a reservoir created by Hartwell Dam. Under the waters of Lake Hartwell the Seneca River joins the Tugaloo River to form the Savannah River. The Seneca River was in the heart of the Cherokee Lower Towns. A Cherokee town known as "Seneca" (or Isunigu) was on the banks of the river near the British Fort Prince George.
