Santa María or Santa Maria may refer to:
- The name of the Blessed Virgin Mary or Mary, the mother of Jesus, in various languages such as Italian, Portuguese, Spanish and Catalan
- Santa Maria Island, one of the islands of the Azores
- The name of two well-known ships:
- Santa María (ship) - the largest of the three ships used by Christopher Columbus in his 1492 voyage across the Atlantic Ocean
- Santa Maria hijacking - the hijacking of the Portuguese ocean liner Santa Maria in 1961
- Santa Maria (Cannabis) - a landrace strain of cannabis from the Brazilian Amazon
- Santa Maria (F81) - a Spanish class of frigate
- Aermacchi AL.60, known as AL.60B Santa Maria - an Italian utility aircraft.
- Santa Maria (band), a portuguese eurodance band.
- "Santa Maria", the third movement of Mike Oldfield's The Millennium Bell album.
As a toponym
Argentina
- Santa María, Catamarca
- Santa María de Punilla
- Santa María, Misiones
- Santa María Centro, Santa Fe
- Santa María Norte, Santa Fe
- Santa María del Buen Ayre, old name of Buenos Aires
Brazil
- Santa Maria, Rio Grande do Sul
- Santa Maria das Barreiras
- Santa Maria da Boa Vista
- Santa Maria do Cambucá, Pernambuco
- Santa Maria do Herval, Rio Grande do Sul
- Santa Maria de Itabira, Minas Gerais
- Santa Maria de Jetibá, Espírito Santo
- Santa Maria Madalena, Rio de Janeiro
- Santa Maria do Oeste, Paraná
- Santa Maria do Pará, Pará
- Santa Maria do Salto, Minas Gerais
- Santa Maria da Serra, São Paulo
- Santa Maria do Suaçuí, Minas Gerais
- Santa Maria do Tocantins, Tocantins
- Santa Maria da Vitória, Bahia
Chile
- Santa María, Chile
Cape Verde
Colombia
Guatemala
- Santa María Cahabón
- Santa María Chiquimula
- Santa María Ixhuatán
- Santa María Visitación
- Santa María de Jesús
- Santa María (volcano)
Italy
- Santa Maria (Ponza)
- Santa Maria, Schio, Italy, a neighborhood of Schio
- Santa Maria Zobenigo or Santa Maria del Giglio, a church in Venice
Mexico
- Misión Santa María de los Ángeles, Baja California
- Santa María, Campeche
- Santa María, Chiapas
- Santa María, Hidalgo
- Santa María, Michoacán
- Santa María, Sinaloa
- Santa Maria del Oro, Durango
Portugal
- Santa Maria Island, in the Azores
- Cabo de Santa Maria, a cape south of Faro, the southernmost point of mainland Portugal
- Santa Maria (Bragança), a parish (freguesia) in the municipality of Bragança
- Santa Maria (Celorico da Beira), a parish in the municipality of Celorico da Beira
- Santa Maria (Covilhã), a parish in the municipality of Covilhã
- Santa Maria, a parish in the municipality of Estremoz
- Santa Maria, a parish in the municipality of Lagos
- Santa Maria, a parish in the municipality of Manteigas
- Santa Maria, a parish in the municipality of Óbidos
- Santa Maria, a parish in the municipality of Odemira
- Santa Maria, a parish in the municipality of Serpa
- Santa Maria, a parish in the municipality of Tavira
- Santa Maria, a parish in the municipality of Torres Novas
- Santa Maria, a parish in the municipality of Trancoso
Philippines
- Santa Maria, Bulacan
- Santa Maria, Davao del Sur
- Santa Maria, Ilocos Sur
- Santa Maria, Isabela
- Santa Maria, Laguna
- Santa Maria, Pangasinan
- Santa Maria, Romblon
- Santa Maria, Macabebe
Spain
- In Barcelona:
- Santa Maria de Besora
- Santa Maria de Corcó
- Santa Maria de Martorelles
- Santa Maria de Merlès
- Santa Maria de Miralles
- Santa Maria de Palautordera
- Santa Maria d'Oló
- In Burgos:
- Santa María de Ananúñez
- Santa María de Garoña
- Santa María de Tajadura
- Santa María del Campo
- Santa María del Invierno
- Santa María del Llano de Tudela
- Santa María del Mercadillo
- Santa María Ribarredonda
- In Cádiz:
- In Gran Canaria:
- In León:
- In Salamanca:
- In Tarragona:
- In Toledo:
Switzerland
United States
Vanuatu
- Gaua, known as Santa Maria Island, one of the Banks Islands
