Roxanne is a female given name. It was originally an alternate spelling of Roxane, the French form of Roxana, but it has been regularly used in English speaking countries since the 1930s. Roxanne may refer to:
- A major hurricane in October 1995 - see Hurricane Roxanne
- A song by The Police - see Roxanne (song)
- A 1987 movie adaptation of Cyrano de Bergerac with Steve Martin and Daryl Hannah - see Roxanne (film)
- An animated character - see Roxanne (Pokémon)
- A reference to the song by U.T.F.O. Roxanne, Roxanne and the rejoinder Roxanne's Revenge by Roxanne Shanté - also see Roxanne Wars
- A fictional character from Walt Disney's A Goofy Movie
- The name of one of Alexander the Great's wives, commonly spelled Roxana
- The marketing/communications/online music and entertainment journalist Roxanne Blanford known throughout the 1990s and 2000s for interviewing and reviewing primarily independent music acts
- The name of the assistant on the 1950-1961 game show Beat the Clock - see Roxanne (model)
- The usual Western spelling of the Persian feminine name Roshanak
- A number of female hip-hop artists, including Roxanne Shanté and The Real Roxanne, a trend initiated by the Roxanne Wars
- Introduced in R. Kelly's Trapped in the Closet Chapter- 14 played by Erika Ringor
