RPG is an abbreviation with several different meanings:
- RPG programming language, a native programming language for IBM's System i servers
- RPG Life Sciences, an Indian pharmaceutical company
- Role-playing game, a game in which players assume the roles of characters and collaboratively create narratives
- Tabletop role-playing game, also called traditional roleplaying games in which participants usually sit around a table and conduct the game as a small social gathering
- Computer role-playing game (sometimes CRPG), a computer game with the setting and game mechanics of a role-playing game
- Console role-playing game, a CRPG for video game consoles
- Tactical role-playing game, a video game with both CRPG and turn-based strategy elements
- Online text-based role-playing game, a role-playing game played online using a solely text-based interface such as TELNET, an internet forum, or in a chat
- Rocket-propelled grenade, a type of hand-held antitank weapon
- Rebounds per game, in basketball
- Robert P. George, a professor at Princeton University
