It includes 70 comuni (singular: comune), ranging in area from Viadana, with 102.19 km², to Mariana Mantovana, with 8.81 km². The main comuni by population are:
Mantua is surrounded on three sides by lakes. It has three central piazzas, including the famous Piazza Mantegna. Mantua is home to the Gonzaga family's mansion. A relic of Christ's Blood is buried in the local Basilica di Sant'Andrea. The Blood of Christ militia originated in Mantua because of this relic.