Poe is the surname of:
- Edgar Allan Poe (1809-1849), American writer
- John Poe (fl. 1980s), drummer from rock band Guadalcanal Diary
- Fernando Poe, Sr., Filipino actor
- Fernando Poe, Jr., son of Poe, Sr., also a famous actor and a former candidate for President of the Philippines
- Marshall Poe, American historian and author
- Michael Poe (fl. 2000s), American webcomics artist
- Ted Poe ( born 1948), U.S. Congressman for the 2nd Congressional District of Texas.
In fiction:
- Arthur Poe, fictional character in the A Series of Unfortunate Events book series
- Cameron Poe, fictional character in the movie Con Air
