| BCL2 binding component 3 | |
|---|---|
| Symbol(s): | BBC3 |
| Other names: | JFY1, PUMA |
| Genetic data | |
| Locus: | Chr. 19 q13.3 |
| Database Links | |
| Entrez: | 27113 |
| OMIM: | 17868 |
| RefSeq: | NM_014417 |
| UniProt: | Q9BXH1 |
The p53 upregulated modulator of apoptosis, or PUMA, is a pro-apoptotic member of the Bcl-2 protein family.[1] Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The expression of PUMA is regulated by the tumor suppressor p53, and PUMA has been shown to be involved in p53-mediated apoptosis.
See also
- Apoptosis
- Apoptosome
- Bcl-2
- Bcl-2-associated_X_protein (BAX)
- BH3 interacting domain death agonist (BID)
- Caspases
- Cytochrome c
- Noxa
- Mitochondrion
References
- ^ Nakano, K.; and Vousden, K. H. (March 2001). "PUMA, a Novel Proaptotic Gene, is Induced by p53". Molecular Cell 7: 683-694.
