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Not What You Meant?  There are 23 definitions for Substitution.

Opiate replacement therapy

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Opiate Replacement Therapy (ORT) is the medical procedure of replacing an illegal opiate drug such as heroin with a longer acting but less euphoric opiate such as methadone or buprenorphine. Drugs such as buprenorphine are manufactured in pill form with the opiate antagonist Naloxone to prevent addicts from crushing the tablets and injecting them instead of taking them sublingually (under the tongue). The driving principle behind ORT is that an opiate addict will be able to regain a normal life and schedule by dosing themselves with a pill that stops them from experiencing withdrawal symptoms, but doesn't provide radical euphoria that drugs like heroin do. The theory behind use of ORT is that as a result, addicts will live normal lives.

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Opiate replacement therapy from Wíkipedia. ©2006 by Wíkipedia. Licensed under the GNU Free Documentation License. View a list of authors or edit this article.

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