Middle America may refer to:
- Middle America (Americas), a region comprising the mid-latitudes of the Americas.
- Middle America (United States), a political reflection of those living in the interior of the continental United States by those living in its coastal areas; also, the American middle class, especially its traditional or conservative elements.
- the Midwestern United States
- uncommonly, Mesoamerica, the area inhabited by the pre-Columbian empires that extended from central Mexico southward through much of Central America.
