MacManus is a family name that may refer to:
- Arthur MacManus, Scottish trade unionist and political activist
- Declan MacManus (born 1954), English musician, singer and songwriter
- Henry MacManus (c.1810–1878), Irish painter
- Joseph MacManus (1970–1992), member in the Sligo Brigade of the Provisional Irish Republican Army
- Ross MacManus (born 1927), British musician and trumpet player
- Seán MacManus, former Mayor of Sligo and Sinn Féin policitian, father of Joseph MacManus
- Steve MacManus, British comic writer
- Terence MacManus (c.1811–1861), a radical Irish rebel
