Lilo can refer to:
- Lilo Training Detachment of Frontier Troops, located just outside Tbilisi city, the capital of the country of Georgia
- LILO, a bootloader for Linux
- Rob Levin, the founder of the freenode IRC network, whose nickname was lilo in lowercase
- Carmine Galante, the boss of Bonanno crime family, whose nickname was lilo
- an inflatable air mattress, a swimming pool toy, a generic lower case noun not to be confused with the hyphenated trademark
- Lilo Pelekai, one of the main characters of Disney's 41st animated film, Lilo & Stitch
- Lilo, a French actress and singer who was the leading lady in the Broadway production of Can-Can (musical)
- Lilo, a village in County Armagh, Northern Ireland
- Lilo Lil was a character in the BBC television sitcom Bread
- Lilo or Li-Lo, references to Lindsay Lohan in the British celebrity press that ape the reference J-lo for Jennifer Lopez (also L-lo).
LILO is an acronym for:
- Last In, Last Out, a technical concept logically equivalent to the more common FIFO
- Left In, Left Out, a geometric configuration for a roadway intersection
- Lease In Lease Out, a type of tax shelter in which strategic leasing is used to create losses
