Larissa is a city in Greece. Larissa may also refer to:
- Larissa Prefecture, an administrative division of Greece, centered on the city Larissa
- AEL 1964, a football club from Larissa
- Larissa (mythology), a nymph from Greek mythology
- Larissa (Argolis), the acropolis of Argos in Greece
- Larissa (moon), a moon of Neptune
- 1162 Larissa, an asteroid
- Larissa, Turkey, an ancient city in Turkey, in the immediate vicinity of Menemen district of İzmir
- Larisa (film), a 1980 short film directed by Elem Klimov
