James Harrison may refer to:
- James Harrison (justice) (fl. 1680s), justice of the Pennsylvania Supreme Court
- James Harrison (engineer) (1816–1893), Australian newspaper editor and engineer who developed an ice-making machine
- James Harrison (Australian governor) (1912–1971), Governor of South Australia
- James Harrison (politician), Australian Labor Party member of the Australian House of Representatives from 1949 to 1969 representing Blaxland
- James M. Harrison (1915–1990), Canadian scientist and public servant
- James Harwood Harrison (1907–1980), British Conservative Member of Parliament
- James Harrison (football player) (born 1978), American football player
- James Harrison (Labour politician) (1899–1959), British Member of Parliament from Nottingham
- James Harrison (commandant), USDB Commandant
- James Harrison (Student), Guernsey/Portsmouth Student and Film Maker


